منابع مشابه
History of the use of colchicum and related medicaments in gout; with suggestions for further research.
This brief history of the use of extracts of Colchicum autumnale in the treatment of gout had its origin in some research relative to the metabolism and mode of action of colchicine. It was interesting to review this history in order to develop a background, and thus to learn what ancient authorities and later observers knew about this drug. We shall review the evidence for the identity of cert...
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A 39-year-old man was admitted to hospital because of vomiting and diarrhoea. He had developed cardiomyopathy of unknown cause a decade earlier that was managed with diuretics and an angiotensin-converting enzyme inhibitor. Two years thereafter, insulindependent diabetes mellitus appeared. His HbA1c was controlled at 7.5%. Two weeks prior to admission, he developed a burning pain in both feet. ...
متن کاملCase report: fatal poisoning with Colchicum autumnale
INTRODUCTION Colchicum autumnale, commonly known as the autumn crocus, contains alkaloid colchicine with antimitotic properties. CASE REPORT A 76-year-old man with a history of alcoholic liver disease and renal insufficiency, who mistakenly ingested Colchicum autumnale instead of wild garlic (Aliium ursinum), presented with nausea, vomiting and diarrhea 12 hours after ingestion. On admission ...
متن کاملGout. Mechanisms of inflammation in gout
An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activat...
متن کاملGout. Epidemiology of gout
Gout is the most prevalent form of inflammatory arthropathy. Several studies suggest that its prevalence and incidence have risen in recent decades. Numerous risk factors for the development of gout have been established, including hyperuricaemia, genetic factors, dietary factors, alcohol consumption, metabolic syndrome, hypertension, obesity, diuretic use and chronic renal disease. Osteoarthri...
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ژورنال
عنوان ژورنال: The Boston Medical and Surgical Journal
سال: 1843
ISSN: 0096-6762,1533-4406
DOI: 10.1056/nejm184312270292106